Last updated: 2024-06-15
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| File | Version | Author | Date | Message |
|---|---|---|---|---|
| Rmd | 63dbdbd | Sarah Urbut | 2024-06-15 | Update |
| html | 63dbdbd | Sarah Urbut | 2024-06-15 | Update |
| html | 3c8102f | Sarah Urbut | 2024-06-13 | Update |
| Rmd | ae5b719 | Sarah Urbut | 2024-06-13 | Update |
| html | ae5b719 | Sarah Urbut | 2024-06-13 | Update |
| html | 490e529 | Sarah Urbut | 2024-06-13 | Update |
| Rmd | 88231db | Sarah Urbut | 2024-06-13 | Update |
| html | 88231db | Sarah Urbut | 2024-06-13 | Update |
| Rmd | 111b7d1 | Sarah Urbut | 2024-06-13 | update |
| html | 111b7d1 | Sarah Urbut | 2024-06-13 | update |
| Rmd | e42fc49 | Sarah Urbut | 2024-06-13 | update |
| html | e42fc49 | Sarah Urbut | 2024-06-13 | update |
| Rmd | 7cc198e | Sarah Urbut | 2024-06-12 | update |
| html | 7cc198e | Sarah Urbut | 2024-06-12 | update |
| html | 8a9060f | Sarah Urbut | 2024-06-12 | Update |
| Rmd | cef5b27 | Sarah Urbut | 2024-06-12 | Update |
| html | cef5b27 | Sarah Urbut | 2024-06-12 | Update |
| html | 9d06964 | Sarah Urbut | 2024-06-12 | Update |
| Rmd | c48abee | Sarah Urbut | 2024-06-12 | Update |
Welcome to a detailed reproduction of all analyses in the Dynamic Hazard paper, Urbut et al 2024.
Figure 1 Here is the hazard rate and proportion of variation explained in the UK Biobank and
Figure 1b Here is the hazard rate and proportion of variation explained in the Framingham Offspring Cohort
Figure 2 Here are the relative and absolute rates of CAD by PRS and PCE percentile for three age categories
Figure 3 Here is the stratification by age and PCE using the UK Biobank
Figure 4 Here is the proportion of future events captured using a PCE threshold of 7.5% versus a PRS threshold of greater than 80% to predict future events
Figure 1 Supplemental Here is the net reclassification of events and non events using PCE versus PRS
Figure 2 Supplemental Here is the proportion of individuals in each PCE risk class by age
Proportional Hazards Here is the demonstration cox PH is violated with typical model.
Cumulative Events Here I plot cumulative events by ACVD strata or by age.
Density Plots Here I show PRS distirbution for overall cohort, and for ours, with different scaling.
Lipid Plot Here I show detailed analysis of statin use by age of enrollment in the FOS.
Age of Menopause Plot Here I show detailed analysis of hazard ratios by sex in FOS and age of enrollment by menopause.
Sex Specific Thresholding Here I show detailed analysis of proportion of events assessed, Age of event, and AUC using females only.
Sex Specific Thresholding Here I show detailed analysis of the relationships between absolute and relative PRS in females only.
Sex Specific Thresholding Here I show detailed analysis of the relationships between absolute and relative PRS in males only.
We also have a variety of exlucsion tables and summary tables
Table 1 Here is the summary characterisitics of each cohort, and of division by ASCVD and PRS risk calss in the UK Biobank subset
Exclusions Here are the flowcharts of exclusionary criteria for creating the cohorts used in these analyses.